To know about 2019 Novel Coronavirus (2019 - nCoV)

Key Facts:

2019 Novel Coronavirus (2019-nCoV) is a virus (more specifically, a coronavirus)identified as the cause of an outburst of respiratory illness first spotted in Wuhan, China.

Right off the bat, a significant number of the patients in Wuhan, China reportedly had some link to a large seafood and animal market, signifying animal-to-person spread. Though, a rising patient's number allegedly have not had contact to animal markets, indicating person-to-person spread is occurring.

Recent Updates

Recent Updates: :
  • As per the report published in Worldometer, 10 additional cases confirmed on board the cruise ship in Japan.

  • Recently, 1 new case in the United States (Wisconsin).

  • Newly, 3 new coronavirus cases in South Korea; 2 men had travelled to Singapore for conference.

  • Currently, 4 new cases confirmed in Singapore, including a six-month-old child of an infected couple.

  • As reported, 2 new cases in Malaysia, 1 new case in Australia (Queensland).

  • As reported, 1 death reported from Tianjin, China: the patient had developed fever and cough after shopping in a department store on January 22. The patient had a history of type 2 diabetes and hypertension.

Catastrophic Scenario

Incubation Period (Symptoms to Appear):

Treatment and Precautions

As per the global scenario, the preventive measures published by CDC is as follows

For treatment purpose, no specific antiviral treatment recommended for 2019- nCoV infection. Precisely, Remdesivir (antiviral drug, nucleotide analog), producing by Gilead, is recently came in existence for the treatment and as report it is in trial phase in China.

The Omics of (2019-nCoV):

Scientific Study Suggested by AKS University

Department of Biotechnology of AKS University had run a "Fast Track Computational Prediction Program" for Coronavirus (2019 - nCoV). The research panel decided to analyze the sequences and further move towards, homology modelling, structure validation and finalize the pipeline as molecular Docking. As treatment, the department of biotechnology had confirmed the biological role of Cordycepin (isolated from fungi - Cordyceps militaris), Cordyceps (important traditional medicinal mushrooms) is utilized to prevent coughs, chronic bronchitis, respiratory disorders, kidney disorders and anaemia. It was also suggested in reports that it helps in preventing male sexual problems, irregular heartbeat, high cholesterol, liver disorders and also prevent weight loss. It has been reported that Cordycepin shows anti-carcinogenic activity

Research wing of department applied "Computational Prediction Model (CPM)" for Cordycepin to validate them acting as potential inhibitor for various structural and non-structural proteins of Coronavirus.

On the basis of structure predictions and energy calculations on different structural proteins (S, M, E proteins) mainly, Nucleocapsid N protein, main physical constituent of capsid, that fluxes RNA pack, links the capsid for envelope, helpful in processing viral replication and evasion of the immune system. M protein of coronavirus acts majorly in virus assembly and helpful in turning cellular films into platforms where virus and host factors converge to make new virus particles. ORF5 determined as RNA Dependent RNA Polymerase enzyme, enables viral RNA replications in host by virus.

Biotech. Dept. of AKS University, predicted with the help of CPM that Cordycepin is showing inhibition effects on (N, M, E and orf5) structural and non-structural proteins of Coronavirus. The FASTA format sequence were obtained from NCBI and further pipeline of (CPM) were followed to determine the docking and energy calculations. The detailed report were submitted to 'The Lancet'.

S.No. Parameters for CORDYCEPIN Description
1 Accession Number DB12156
2 Type Small Molecule
3 Weight Average: 251.2419Mono-isotopic: 251.101839307
4 Chemical Formula C 10 H 13 N 5 O 3
5 Water Solubility 11.3 mg/mL
6 Rule of Five YES

Predicted Properties of Cordycepin: